Permeation of Chlorhexidine from Alcoholic and Aqueous Solutions within Excised Human Skin | Zendy

T.J. Karpanen | Zendy; T. Worthington | Zendy; Barbara R. Conway | Zendy; Anthony C. Hilton | Zendy; Thomas Elliott | Zendy; Peter A. Lambert | Zendy

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Permeation of Chlorhexidine from Alcoholic and Aqueous Solutions within Excised Human Skin

Author(s) -

T.J. Karpanen,

T. Worthington,

Barbara R. Conway,

Anthony C. Hilton,

Thomas Elliott,

Peter A. Lambert

Publication year - 2009

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01289-08

Subject(s) - chlorhexidine , permeation , aqueous solution , chemistry , medicine , chromatography , microbiology and biotechnology , biology , dentistry , organic chemistry , biochemistry , membrane

Chlorhexidine digluconate (CHG) is widely used in the clinical setting for skin antisepsis prior to incision or insertion of medical devices, e.g., central venous catheters (11-13); however, its permeation into skin is limited (6, 7, 9, 10, 16). In a recent study, we demonstrated the limited penetration of CHG in a skin model comprising full-thickness excised human skin following the application of 2% (wt/vol) aqueous CHG (9). The aim of this current study was to compare the penetration of chlorhexidine into skin following the topical application of 2% (wt/vol) CHG in 70% (vol/vol) isopropyl alcohol (IPA) with that of aqueous CHG.

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