CMY-31 and CMY-36 Cephalosporinases Encoded by ColE1-Like Plasmids | Zendy

A. Zioga | Zendy; Jean M. Whichard | Zendy; Stathis D. Kotsakis | Zendy; L. S. Tzouvelekis | Zendy; Εva Tzelepi | Zendy; Vivì Miriagou | Zendy

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CMY-31 and CMY-36 Cephalosporinases Encoded by ColE1-Like Plasmids

Author(s) -

A. Zioga,

Jean M. Whichard,

Stathis D. Kotsakis,

L. S. Tzouvelekis,

Εva Tzelepi,

Vivì Miriagou

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01284-08

Subject(s) - cole1 , plasmid , computational biology , biology , genetics , gene

Two CMY-2 derivatives, CMY-31 (Gln215 →Arg) fromSalmonella enterica serotype Newport and CMY-36 (Ala77 →Cys and Gln193 →Glu) fromKlebsiella pneumoniae , were characterized. Both cephalosporinases functionally resembled CMY-2.bla CMY alleles occurred as parts of a putative transposon comprising ISEcp1B and aCitrobacter freundii -derived sequence carried by ColE1-like plasmids similar to CMY-5-encoding pTKH11 fromKlebsiella oxytoca .

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