Roles of Lytic Transglycosylases in Biofilm Formation and β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus | Zendy

Anne-Aurélie Lopes | Zendy; Yutaka Yoshii | Zendy; Satomi Yamada | Zendy; Mari Nagakura | Zendy; Yuki Kinjo | Zendy; Yoshimitsu Mizunoe | Zendy; Ken-ichi Okuda | Zendy

Open Access

Roles of Lytic Transglycosylases in Biofilm Formation and β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus

Author(s) -

Anne-Aurélie Lopes,

Yutaka Yoshii,

Satomi Yamada,

Mari Nagakura,

Yuki Kinjo,

Yoshimitsu Mizunoe,

Ken-ichi Okuda

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01277-19

Subject(s) - microbiology and biotechnology , staphylococcus aureus , lytic cycle , biofilm , staphylococcus epidermidis , biology , staphylococcal infections , antibiotic resistance , antibiotics , methicillin resistant staphylococcus aureus , bacteria , virology , virus , genetics

Staphylococcus aureus is responsible for numerous community outbreaks and is one of the most frequent causes of nosocomial infections with significant morbidity and mortality. While the function of lytic transglycosylases (LTs) in relation to cell division, biofilm formation, and antibiotic resistance has been determined for several bacteria, their role inS. aureus remains largely unknown. The only known LTs inS. aureus are immunodominant staphylococcal antigen A (IsaA) andStaphylococcus epidermidis D protein (SceD).

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