Open AccessCharacterization of an Enterobacter cloacae Strain Producing both KPC and NDM Carbapenemases by Whole-Genome Sequencing
Author(s) -
Wenjing Wu,
Yu Feng,
Alessandra Carattoli,
Zhiyong Zong
Publication year - 2015
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01275-15
Subject(s) - enterobacter cloacae , biology , plasmid , whole genome sequencing , strain (injury) , carbapenem , microbiology and biotechnology , genome , gene , genetics , enterobacteriaceae , antibiotics , escherichia coli , anatomy
A carbapenem-resistantEnterobacter cloacae strain, WCHECl-14653, causing a fatal bloodstream infection, was characterized by genome sequencing and conjugation experiments. The strain carried two carbapenemase genes,bla NDM-1 andbla KPC-2 , on separate IncF plasmids. The coexistence ofbla NDM-1 andbla KPC-2 conferred slightly higher-level carbapenem resistance compared with that ofbla NDM-1 orbla KPC-2 alone, and the coexistence of two IncF plasmids may generate new platforms for spreading carbapenemase genes.
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