Open AccessAntifungal Susceptibility Profile of Human-Pathogenic Species of Lichtheimia
Author(s) -
Ana AlastrueyIzquierdo,
Isabel Cuesta,
Grit Walther,
Manuel CuencaEstrella,
Juan Luis Rodríguez-Tudela
Publication year - 2010
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01270-09
Subject(s) - posaconazole , voriconazole , echinocandins , azole , amphotericin b , biology , microbiology and biotechnology , antifungal , drug , in vitro , pharmacology , caspofungin , biochemistry
Forty-four isolates belonging to human pathogenic species ofLichtheimia were tested against nine antifungal agents by using the EUCAST methodology. No remarkable differences were found between the clinical species, althoughL. ramosa showed slightly higher MICs for all drugs. Amphotericin B was the most active drug. Among azole drugs, posaconazole had the best activityin vitro and voriconazole was inactive. Echinocandins showed activity for some isolates, suggesting a potential role in combination therapy.