Open AccessIncreasing Genetic Relatedness of Ciprofloxacin-Resistant Streptococcus pneumoniae Isolated in Canada from 1997 to 2005
Author(s) -
Kim Nichol,
Heather J. Adam,
James A. Karlowsky,
George G. Zhanel,
Daryl J. Hoban
Publication year - 2008
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01260-07
Subject(s) - pulsed field gel electrophoresis , streptococcus pneumoniae , ciprofloxacin , microbiology and biotechnology , biology , gel electrophoresis , homogeneity (statistics) , genotype , streptococcaceae , genetics , gene , antibiotics , statistics , mathematics
The genetic relatedness of ciprofloxacin-resistantStreptococcus pneumoniae isolates collected from 1997 to 2002 (n = 82) and 2003 to 2005 (n = 123) was compared by pulsed-field gel electrophoresis (PFGE). Increased genetic homogeneity among the isolates from 2003 to 2005 (cluster analysis;P < 0.001) appeared to be due to expansion of existing clonal groups and to introduction of new PFGE types.