Attenuated Vancomycin Bactericidal Activity against Staphylococcus aureus hemB Mutants Expressing the Small-Colony-Variant Phenotype | Zendy

Brian T. Tsuji | Zendy; Christof von Eiff | Zendy; Pamela Kelchlin | Zendy; Alan Forrest | Zendy; Patrick F. Smith | Zendy

Open Access

Attenuated Vancomycin Bactericidal Activity against Staphylococcus aureus hemB Mutants Expressing the Small-Colony-Variant Phenotype

Author(s) -

Brian T. Tsuji,

Christof von Eiff,

Pamela Kelchlin,

Alan Forrest,

Patrick F. Smith

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01254-07

Subject(s) - staphylococcus aureus , vancomycin , microbiology and biotechnology , phenotype , mutant , micrococcaceae , biology , antibacterial agent , in vitro , bacteria , antibiotics , gene , genetics

The in vitro bactericidal activities of vancomycin against Staphylococcus aureus hemB mutants displaying the small-colony-variant phenotype and their parental strains were evaluated. Vancomycin killing activities against hemB mutants were markedly attenuated, demonstrating approximately 50% less effect, a result which was well described by a Hill-type pharmacodynamic model.

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