Safety, Tolerability, and Pharmacokinetics of Oral Nafithromycin (WCK 4873) after Single or Multiple Doses and Effects of Food on Single-Dose Bioavailability in Healthy Adult Subjects | Zendy

Piotr Iwanowski | Zendy; Ashima Bhatia | Zendy; Mugdha Gupta | Zendy; Anasuya Patel | Zendy; Rajesh Chavan | Zendy; Ravindra Yeole | Zendy; David Friedland | Zendy

Open Access

Safety, Tolerability, and Pharmacokinetics of Oral Nafithromycin (WCK 4873) after Single or Multiple Doses and Effects of Food on Single-Dose Bioavailability in Healthy Adult Subjects

Author(s) -

Piotr Iwanowski,

Ashima Bhatia,

Mugdha Gupta,

Anasuya Patel,

Rajesh Chavan,

Ravindra Yeole,

David Friedland

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01253-19

Subject(s) - bioavailability , pharmacokinetics , tolerability , placebo , pharmacology , medicine , oral administration , adverse effect , alternative medicine , pathology

Nafithromycin (WCK 4873), a novel lactone-ketolide, was administered to healthy adult subjects in 2 randomized, double-blind, placebo-controlled, phase 1 studies. In the first-in-human study, single ascending oral doses of nafithromycin (100 to 1,200 mg) were administered to subjects under fasted or fed conditions, with effects of food on bioavailability of nafithromycin studied at the dose levels of 400 and 800 mg.

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