Inhibition of Protein Secretion in Escherichia coli and Sub-MIC Effects of Arylomycin Antibiotics | Zendy

Shawn I. Walsh | Zendy; David S. Peters | Zendy; Peter A. Smith | Zendy; Arryn Craney | Zendy; Melissa M. Dix | Zendy; Benjamin F. Cravatt | Zendy; Floyd E. Romesberg | Zendy

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Inhibition of Protein Secretion in Escherichia coli and Sub-MIC Effects of Arylomycin Antibiotics

Author(s) -

Shawn I. Walsh,

David S. Peters,

Peter A. Smith,

Arryn Craney,

Melissa M. Dix,

Benjamin F. Cravatt,

Floyd E. Romesberg

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01253-18

Subject(s) - antibiotics , microbiology and biotechnology , virulence , escherichia coli , bacteria , biology , secretion , antibiotic resistance , horizontal gene transfer , gene , genetics , biochemistry , phylogenetic tree

At sufficient concentrations, antibiotics effectively eradicate many bacterial infections. However, during therapy, bacteria are unavoidably exposed to lower antibiotic concentrations, and sub-MIC exposure can result in a wide variety of other effects, including the induction of virulence, which can complicate therapy, or horizontal gene transfer (HGT), which can accelerate the spread of resistance genes.

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