Effect of Pregnancy on the Pharmacokinetic Interaction between Efavirenz and Lumefantrine in HIV-Malaria Coinfection | Zendy

Adebanjo J. Adegbola | Zendy; Rana Abutaima | Zendy; Adeniyi Olagunju | Zendy; Omotade Adebimpe Ijarotimi | Zendy; Marco Siccardi | Zendy; Andrew Owen | Zendy; Julius O. Soyinka | Zendy; Oluseye O. Bolaji | Zendy

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Effect of Pregnancy on the Pharmacokinetic Interaction between Efavirenz and Lumefantrine in HIV-Malaria Coinfection

Author(s) -

Adebanjo J. Adegbola,

Rana Abutaima,

Adeniyi Olagunju,

Omotade Adebimpe Ijarotimi,

Marco Siccardi,

Andrew Owen,

Julius O. Soyinka,

Oluseye O. Bolaji

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01252-18

Subject(s) - efavirenz , artemether/lumefantrine , lumefantrine , coinfection , pharmacokinetics , malaria , nevirapine , medicine , artemether , pregnancy , pharmacology , antiretroviral therapy , virology , plasmodium falciparum , human immunodeficiency virus (hiv) , viral load , biology , immunology , artemisinin , genetics

Artemether-lumefantrine is often coadministered with efavirenz-based antiretroviral therapy for malaria treatment in HIV-infected women during pregnancy. Previous studies showed changes in lumefantrine pharmacokinetics due to interaction with efavirenz in nonpregnant adults.

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