Heterogeneous Genetic Location of mcr-1 in Colistin-Resistant Escherichia coli Isolates from Humans and Retail Chicken Meat in Switzerland: Emergence of mcr-1 -Carrying IncK2 Plasmids | Zendy

Valentina Donà | Zendy; Odette J. Bernasconi | Zendy; João Pires | Zendy; Alexandra Collaud | Zendy; Gudrun Overesch | Zendy; Alban Ramette | Zendy; Vincent Perreten | Zendy; Andrea Endimiani | Zendy

Open Access

Heterogeneous Genetic Location of mcr-1 in Colistin-Resistant Escherichia coli Isolates from Humans and Retail Chicken Meat in Switzerland: Emergence of mcr-1 -Carrying IncK2 Plasmids

Author(s) -

Valentina Donà,

Odette J. Bernasconi,

João Pires,

Alexandra Collaud,

Gudrun Overesch,

Alban Ramette,

Vincent Perreten,

Andrea Endimiani

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01245-17

Subject(s) - mcr 1 , plasmid , escherichia coli , colistin , biology , microbiology and biotechnology , enterobacteriaceae , genetics , gene , genome , strain (injury) , antimicrobial , anatomy

We characterized the genetic environment ofmcr-1 in colistin-resistantEscherichia coli strains isolated in Switzerland during 2014 to 2016 from humans (n = 3) and chicken meat (n = 6). Whole-genome and plasmid sequencing identified themcr-1 gene integrated in IncX4 (of which, one strain carried themcr-1.2 variant), IncI2, IncHI2, and novel IncK2 plasmids (overall,n = 7), as well as in the bacterial chromosome (n = 2) in single or duplicate copies. Our study supports the easy mobilization ofmcr-1 across diverse genetic locations.

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