Radiofungicidal Effects of External Gamma Radiation and Antibody-Targeted Beta and Alpha Radiation on Cryptococcus neoformans | Zendy

Ruth Bryan | Zendy; Xianchun Huang | Zendy; Aliyah Morgenstern | Zendy; Frank Bruchertseifer | Zendy; Arturo Casadevall | Zendy; Ekaterina Dadachova | Zendy

Open Access

Radiofungicidal Effects of External Gamma Radiation and Antibody-Targeted Beta and Alpha Radiation on Cryptococcus neoformans

Author(s) -

Ruth Bryan,

Xianchun Huang,

Aliyah Morgenstern,

Frank Bruchertseifer,

Arturo Casadevall,

Ekaterina Dadachova

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01245-07

Subject(s) - cryptococcus neoformans , alpha (finance) , clonogenic assay , beta (programming language) , cryptococcus , antibody , biology , microbiology and biotechnology , apoptosis , chemistry , cancer research , immunology , biochemistry , medicine , construct validity , nursing , computer science , patient satisfaction , programming language

We evaluated the clonogenic survival, membrane permeability, metabolic activity (XTT reduction), and apoptosis (FLICA binding) of Cryptococcus neoformans cells subjected to gamma rays from an external source, and beta and alpha particles delivered to fungal cells by capsule-specific antibody. We found that gamma, beta, and alpha radiation affected cells through different pathways.

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