Clotrimazole Dampens Vaginal Inflammation and Neutrophil Infiltration in Response to Candida albicans Infection | Zendy

Duncan Wilson | Zendy; Betty Hebecker | Zendy; David L. Moyes | Zendy; Pedro Miramón | Zendy; Nadja Jablonowski | Zendy; Stephanie Wisgott | Zendy; Stefanie Allert | Zendy; Julian R. Naglik | Zendy; Bernhard Hube | Zendy

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Clotrimazole Dampens Vaginal Inflammation and Neutrophil Infiltration in Response to Candida albicans Infection

Author(s) -

Duncan Wilson,

Betty Hebecker,

David L. Moyes,

Pedro Miramón,

Nadja Jablonowski,

Stephanie Wisgott,

Stefanie Allert,

Julian R. Naglik,

Bernhard Hube

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01244-13

Subject(s) - clotrimazole , candida albicans , proinflammatory cytokine , vulvovaginal candidiasis , inflammation , infiltration (hvac) , immunology , corpus albicans , biology , microbiology and biotechnology , medicine , antifungal , physics , thermodynamics

The pathology of vulvovaginal candidiasis (VVC) caused byCandida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. We investigated the mechanisms by which clotrimazole resolves VVC. Low levels of clotrimazole, which do not block fungal growth, inhibit expression of a “danger response” transcription factor, c-Fos, block production of proinflammatory cytokines, and inhibit neutrophil infiltration to the site of infection.

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