Anti-BK Virus Activity of Nucleoside Analogs | Zendy

Parmjeet Randhawa | Zendy; Jiří Žemlička | Zendy; Andreas Sauerbrei | Zendy; Chris Meier | Zendy; Karl Y. Hostetler | Zendy; James R. Beadle | Zendy; Noush Afarin Farasati | Zendy; YuChen Huang | Zendy; M S Bradley | Zendy

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Anti-BK Virus Activity of Nucleoside Analogs

Author(s) -

Parmjeet Randhawa,

Jiří Žemlička,

Andreas Sauerbrei,

Chris Meier,

Karl Y. Hostetler,

James R. Beadle,

Noush Afarin Farasati,

YuChen Huang,

M S Bradley

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01241-07

Subject(s) - bk virus , in vitro , chemistry , nucleoside , virus , pathogen , nucleoside analogue , stereochemistry , virology , biochemistry , biology , microbiology and biotechnology , genetics , kidney transplantation , kidney

Polyomavirus BK is an important pathogen in transplant recipients with no effective therapy. This study demonstrates that alkoxyalkyl esters of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and fatty acid derivatives of 9-[2-(phosphonomethyoxy)ethyl]adenine (P393 and P405) are potent and selective inhibitors of BK virus replication in vitro, with a 50% effective concentration in the micromolar-to-nanomolar range.

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