Ceftaroline-Resistant, Daptomycin-Tolerant, and Heterogeneous Vancomycin-Intermediate Methicillin-Resistant Staphylococcus aureus Causing Infective Endocarditis | Zendy

Masayuki Nigo | Zendy; Lorena Díaz | Zendy; Lina P Carvajal | Zendy; Truc T. Tran | Zendy; Rafael Ríos | Zendy; Diana Panesso | Zendy; Juan David Garavito | Zendy; William R. Miller | Zendy; Audrey Wanger | Zendy; George M. Weinstock | Zendy; José M. Munita | Zendy; César A. Arias | Zendy; Henry F. Chambers | Zendy

Open Access

Ceftaroline-Resistant, Daptomycin-Tolerant, and Heterogeneous Vancomycin-Intermediate Methicillin-Resistant Staphylococcus aureus Causing Infective Endocarditis

Author(s) -

Masayuki Nigo,

Lorena Díaz,

Lina P Carvajal,

Truc T. Tran,

Rafael Ríos,

Diana Panesso,

Juan David Garavito,

William R. Miller,

Audrey Wanger,

George M. Weinstock,

José M. Munita,

César A. Arias,

Henry F. Chambers

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01235-16

Subject(s) - daptomycin , staphylococcus aureus , microbiology and biotechnology , vancomycin , methicillin resistant staphylococcus aureus , endocarditis , infective endocarditis , medicine , staphylococcal infections , antibiotics , biology , bacteria , surgery , genetics

We report a case of infective endocarditis (IE) caused by ceftaroline-resistant, daptomycin-tolerant, and heterogeneous vancomycin-intermediate methicillin-resistantS. aureus (MRSA). Resistance to ceftaroline emerged in the absence of drug exposure, and the E447K substitution in the active site of PBP2a previously associated with ceftaroline resistance was identified. Additionally, we present evidence of patient-to-patient transmission of the strain within the same unit. This case illustrates the difficulties in treating MRSA IE in the setting of a multidrug-resistant phenotype.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research