Open AccessIn Vitro Activity of Fosfomycin against bla KPC -Containing Klebsiella pneumoniae Isolates, Including Those Nonsusceptible to Tigecycline and/or Colistin
Author(s) -
Andrea Endimiani,
Gopi Patel,
Kristine M. Hujer,
Mahesh Swaminathan,
Federico Pérez,
Louis B. Rice,
Michael R. Jacobs,
Robert A. Bonomo
Publication year - 2009
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01235-09
Subject(s) - tigecycline , fosfomycin , colistin , klebsiella pneumoniae , etest , agar dilution , microbiology and biotechnology , biology , minocycline , agar , antibiotics , minimum inhibitory concentration , escherichia coli , bacteria , gene , genetics , biochemistry
In vitro activity of fosfomycin was evaluated against 68bla KPC -possessingKlebsiella pneumoniae (KpKPC) isolates, including 23 tigecycline- and/or colistin-nonsusceptible strains. By agar dilution, 93% of the overall KpKPC were susceptible (MIC50/90 of 16/64 μg/ml, respectively). The subgroup of 23 tigecycline- and/or colistin-nonsusceptible strains showed susceptibility rates of 87% (MIC50/90 of 32/128 μg/ml, respectively). Notably, 5 out of 6 extremely drug-resistant (tigecycline and colistin nonsusceptible) KpKPC were susceptible to fosfomycin. Compared to agar dilution, disk diffusion was more accurate than Etest.
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