Accelerated Metabolism of Voriconazole and Its Partial Reversal by Cimetidine | Zendy

Brad Moriyama | Zendy; Jason M. Elinoff | Zendy; Robert L. Danner | Zendy; Juan GeaBanacloche | Zendy; Gennethel Pennick | Zendy; Michael G. Rinaldi | Zendy; Thomas J. Walsh | Zendy

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Accelerated Metabolism of Voriconazole and Its Partial Reversal by Cimetidine

Author(s) -

Brad Moriyama,

Jason M. Elinoff,

Robert L. Danner,

Juan GeaBanacloche,

Gennethel Pennick,

Michael G. Rinaldi,

Thomas J. Walsh

Publication year - 2009

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01221-08

Subject(s) - voriconazole , cimetidine , pharmacology , metabolism , dose , aspergillosis , medicine , cytochrome p450 , chemistry , biology , microbiology and biotechnology , immunology , antifungal

We report a case of accelerated metabolism of voriconazole during therapy for invasive pulmonary aspergillosis, resulting in subtherapeutic levels. Target voriconazole levels were restored with high dosages of voriconazole (up to 40 mg/kg of body weight/day) and the addition of cimetidine as a cytochrome P450 enzyme inhibitor.

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