Contributions of yap1 Mutation and Subsequent atrF Upregulation to Voriconazole Resistance in Aspergillus flavus | Zendy

Yuuta Ukai | Zendy; Miho Kuroiwa | Zendy; Naoko Kurihara | Zendy; Hiroki Naruse | Zendy; Tomoyuki Homma | Zendy; Hideki Maki | Zendy; Akira Naito | Zendy

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Contributions of yap1 Mutation and Subsequent atrF Upregulation to Voriconazole Resistance in Aspergillus flavus

Author(s) -

Yuuta Ukai,

Miho Kuroiwa,

Naoko Kurihara,

Hiroki Naruse,

Tomoyuki Homma,

Hideki Maki,

Akira Naito

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01216-18

Subject(s) - voriconazole , aspergillus flavus , downregulation and upregulation , mutation , microbiology and biotechnology , aspergillus , aspergillosis , biology , genetics , antifungal , immunology , gene

Aspergillus flavus is the second most significant pathogenic cause of invasive aspergillosis; however, its emergence risks and mechanisms of voriconazole (VRC) resistance have not yet been elucidated in detail. Here, we demonstrate that repeated exposure ofA. flavus to subinhibitory concentrations of VRCin vitro causes the emergence of a VRC-resistant mutant with a novel resistance mechanism.

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