Adaptation of Mycobacterium tuberculosis to Biofilm Growth Is Genetically Linked to Drug Tolerance | Zendy

Jacob P. Richards | Zendy; Wenlong Cai | Zendy; Nicholas A. Zill | Zendy; Wenjun Zhang | Zendy; Anil K. Ojha | Zendy

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Adaptation of Mycobacterium tuberculosis to Biofilm Growth Is Genetically Linked to Drug Tolerance

Author(s) -

Jacob P. Richards,

Wenlong Cai,

Nicholas A. Zill,

Wenjun Zhang,

Anil K. Ojha

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01213-19

Subject(s) - biofilm , multidrug tolerance , mycobacterium tuberculosis , biology , microbiology and biotechnology , tuberculosis , population , antibiotics , mycobacterium smegmatis , bacteria , genetics , medicine , environmental health , pathology

Mycobacterium tuberculosis spontaneously grows at the air-medium interface, forming pellicle biofilms, which harbor more drug-tolerant persisters than planktonic cultures. The underlying basis for increased persisters inM. tuberculosis biofilms is unknown.

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