Multidrug-Resistant Neisseria gonorrhoeae Isolates from Nanjing, China, Are Sensitive to Killing by a Novel DNA Gyrase Inhibitor, ETX0914 (AZD0914) | Zendy

Xiaohong Su | Zendy; Baoxi Wang | Zendy; Wenjing Le | Zendy; Liu YuRong | Zendy; Chuan Wan | Zendy; Sai Li | Zendy; Richard A. Alm | Zendy; John P. Mueller | Zendy; Peter A. Rice | Zendy

Open Access

Multidrug-Resistant Neisseria gonorrhoeae Isolates from Nanjing, China, Are Sensitive to Killing by a Novel DNA Gyrase Inhibitor, ETX0914 (AZD0914)

Author(s) -

Xiaohong Su,

Baoxi Wang,

Wenjing Le,

Liu YuRong,

Chuan Wan,

Sai Li,

Richard A. Alm,

John P. Mueller,

Peter A. Rice

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01211-15

Subject(s) - neisseria gonorrhoeae , microbiology and biotechnology , gonorrhea , ciprofloxacin , dna gyrase , tetracycline , ceftriaxone , azithromycin , urethritis , cefixime , biology , neisseriaceae , multiple drug resistance , ofloxacin , antibiotics , virology , medicine , escherichia coli , gene , genetics , human immunodeficiency virus (hiv)

We tested the activity of ETX0914 against 187 Neisseria gonorrhoeae isolates from men with urethritis in Nanjing, China, in 2013. The MIC50, MIC90, and MIC range for ETX0914 were 0.03 μg/ml, 0.06 μg/ml, and ≤0.002 to 0.125 μg/ml, respectively. All isolates were resistant to ciprofloxacin, and 36.9% (69/187) were resistant to azithromycin. Of the isolates, 46.5% were penicillinase-producing N. gonorrhoeae (PPNG), 36% were tetracycline-resistant N. gonorrhoeae (TRNG), and 13% (24 isolates) had an MIC of 0.125 μg/ml for ceftriaxone. ETX0914 may be an effective treatment option for gonorrhea.

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