In Vitro Pharmacodynamics of AZD5206 against Staphylococcus aureus | Zendy

Vincent H. Tam | Zendy; KaiTai Chang | Zendy; Zhen Yang | Zendy; Joseph Newman | Zendy; Ming Hu | Zendy

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In Vitro Pharmacodynamics of AZD5206 against Staphylococcus aureus

Author(s) -

Vincent H. Tam,

KaiTai Chang,

Zhen Yang,

Joseph Newman,

Ming Hu

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01208-12

Subject(s) - staphylococcus aureus , pharmacodynamics , microbiology and biotechnology , in vitro , medicine , biology , pharmacology , bacteria , pharmacokinetics , genetics

AZD5206 is a novel antimicrobial agent with potentin vitro activity againstStaphylococcus aureus . We evaluated thein vitro pharmacodynamics of AZD5206 against a standard wild-type methicillin-susceptible strain (ATCC 29213) and a clinical strain of methicillin-resistantS. aureus (SA62). Overall, bacterial killing against a low baseline inoculum was more remarkable. Low dosing exposures and/or high baseline inoculum resulted in early reduction in bacterial burden, followed by regrowth and selective amplification of the resistant population.

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