Open AccessResistance to Linezolid in a Porcine Clostridium perfringens Strain Carrying a Mutation in the rplD Gene Encoding the Ribosomal Protein L4
Author(s) -
Christina Hölzel,
Katrin Harms,
Karin Schwaiger,
Johann Bauer
Publication year - 2010
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01208-09
Subject(s) - clostridium perfringens , strain (injury) , gene , ribosomal protein , mutation , linezolid , microbiology and biotechnology , bacterial protein , biology , clostridiaceae , genetics , virology , bacteria , ribosome , rna , vancomycin , anatomy , staphylococcus aureus
Coresistance to human reserve antibiotics can be selected by antibiotics used in veterinary medicine. AClostridium perfringens strain isolated from pig manure was resistant to the reserve drug linezolid and, simultaneously, resistant against florfenicol and erythromycin. We detected a new mutation in a highly conserved region ofrpl D , encoding protein L4 of the 50S ribosomal subunit. This is the first genetic substantiation of linezolid resistance in the genusClostridium .