Whole-Genome Sequencing for Predicting Clarithromycin Resistance in Mycobacterium abscessus | Zendy

Samuel Lipworth | Zendy; Natasha Hough | Zendy; Laura Leach | Zendy; Marcus Morgan | Zendy; Katie Jeffery | Zendy; Monique Andersson | Zendy; Esther Robinson | Zendy; E. Grace Smith | Zendy; Derrick W. Crook | Zendy; Tim Peto | Zendy; Timothy M. Walker | Zendy

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Whole-Genome Sequencing for Predicting Clarithromycin Resistance in Mycobacterium abscessus

Author(s) -

Samuel Lipworth,

Natasha Hough,

Laura Leach,

Marcus Morgan,

Katie Jeffery,

Monique Andersson,

Esther Robinson,

E. Grace Smith,

Derrick W. Crook,

Tim Peto,

Timothy M. Walker

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01204-18

Subject(s) - mycobacterium abscessus , clarithromycin , biology , genotype , genetics , whole genome sequencing , single nucleotide polymorphism , mutation , genome , gene , mycobacterium , antibiotics , bacteria

Mycobacterium abscessus is emerging as an important pathogen in chronic lung diseases, with concern regarding patient-to-patient transmission. The recent introduction of routine whole-genome sequencing (WGS) as a replacement for existing reference techniques in England provides an opportunity to characterize the genetic determinants of resistance.

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