Colistin Resistance Gene mcr-1 and Its Variant in Escherichia coli Isolates from Chickens in China | Zendy

Yongqiang Yang | Zendy; Yunxia Li | Zendy; Tao Song | Zendy; Yanxian Yang | Zendy; Wei Jiang | Zendy; Anyun Zhang | Zendy; Xinyi Guo | Zendy; Bihui Liu | Zendy; Yongxiang Wang | Zendy; Changwei Lei | Zendy; Rong Xiang | Zendy; Hongning Wang | Zendy

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Colistin Resistance Gene mcr-1 and Its Variant in Escherichia coli Isolates from Chickens in China

Author(s) -

Yongqiang Yang,

Yunxia Li,

Tao Song,

Yanxian Yang,

Wei Jiang,

Anyun Zhang,

Xinyi Guo,

Bihui Liu,

Yongxiang Wang,

Changwei Lei,

Rong Xiang,

Hongning Wang

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01204-16

Subject(s) - mcr 1 , colistin , escherichia coli , plasmid , biology , enterobacteriaceae , microbiology and biotechnology , gene , enterobacteriaceae infections , escherichia coli proteins , strain (injury) , genetics , antibiotics , anatomy

Themcr-1 gene was detected in 5.11% (58/1136) ofEscherichia coli isolates of chicken origin from 13 provinces in China. A novelmcr-1 variant, namedmcr-1.3 , encoding an Ile-to-Val functional variant of MCR-1 was identified in a sequence type 155 (ST155) strain. Anmcr-1.3 -containing IncI2 plasmid, pHeN867 (60,757 bp), was identified. The transfer of pHeN867 led to a 32-fold increase in the MIC of colistin in the recipient, exhibiting an effect on colistin resistance that was similar to that ofmcr-1 .

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