Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae | Zendy

Charles R. Dean | Zendy; David T. Barkan | Zendy; Alun Bermingham | Zendy; Johanne Blais | Zendy; Fergal Casey | Zendy; Anthony Casarez | Zendy; Richard A. Colvin | Zendy; John Fuller | Zendy; Adriana K. Jones | Zendy; Cindy Li | Zendy; Sara López | Zendy; Louis E. Metzger | Zendy; Mina Mostafavi | Zendy; Ramadevi Prathapam | Zendy; Dita Rasper | Zendy; Folkert Reck | Zendy; Alexey Ruzin | Zendy; Jacob Shaul | Zendy; Xiaoyu Shen | Zendy; Robert L. Simmons | Zendy; Peter Skewes-Cox | Zendy; Kenneth T. Takeoka | Zendy; Pramila Tamrakar | Zendy; Tsuyoshi Uehara | Zendy; Jun-Rong Wei | Zendy

Open Access

Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae

Author(s) -

Charles R. Dean,

David T. Barkan,

Alun Bermingham,

Johanne Blais,

Fergal Casey,

Anthony Casarez,

Richard A. Colvin,

John Fuller,

Adriana K. Jones,

Cindy Li,

Sara López,

Louis E. Metzger,

Mina Mostafavi,

Ramadevi Prathapam,

Dita Rasper,

Folkert Reck,

Alexey Ruzin,

Jacob Shaul,

Xiaoyu Shen,

Robert L. Simmons,

Peter Skewes-Cox,

Kenneth T. Takeoka,

Pramila Tamrakar,

Tsuyoshi Uehara,

Jun-Rong Wei

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01200-18

Subject(s) - klebsiella pneumoniae , escherichia coli , microbiology and biotechnology , mode of action , in vitro , enterobacteriaceae , klebsiella , biology , escherichia , genetics , gene , toxicology

The monobactam scaffold is attractive for the development of new agents to treat infections caused by drug-resistant Gram-negative bacteria because it is stable to metallo-β-lactamases (MBLs). However, the clinically used monobactam aztreonam lacks stability to serine β-lactamases (SBLs) that are often coexpressed with MBLs.

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