Validation of Heel Stick Microsampling To Optimize Micafungin Doses in Neonates and Young Infants | Zendy

Cinzia Auriti | Zendy; Bianca Maria Goffredo | Zendy; Maria Paola Ronchetti | Zendy; Fiammetta Piersigilli | Zendy; Sara Cairoli | Zendy; Iliana Bersani | Zendy; Andrea Dotta | Zendy; Manjunath P. Pai | Zendy

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Validation of Heel Stick Microsampling To Optimize Micafungin Doses in Neonates and Young Infants

Author(s) -

Cinzia Auriti,

Bianca Maria Goffredo,

Maria Paola Ronchetti,

Fiammetta Piersigilli,

Sara Cairoli,

Iliana Bersani,

Andrea Dotta,

Manjunath P. Pai

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01199-18

Subject(s) - micafungin , pharmacokinetics , medicine , therapeutic drug monitoring , heel , dosing , bioanalysis , drug , critically ill , plasma concentration , pharmacology , intensive care medicine , chemistry , chromatography , antifungal , amphotericin b , dermatology , anatomy

Major gaps exist in our knowledge of antimicrobial pharmacokinetics in critically ill neonates and infants that require validated microsampling and bioanalysis methods to support therapeutic drug monitoring. We compared serially collected intravenous (i.v.) and heel stick capillary (HSC)-sampled plasma concentrations of micafungin (8 mg/kg) in eight infants born preterm with systemic candidiasis.

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