Genetic and Biochemical Characterization of OXA-535, a Distantly Related OXA-48-Like β-Lactamase | Zendy

Laura Dabos | Zendy; Agnès B. Jousset | Zendy; Rémy A. Bonnin | Zendy; Nicolas Fortineau | Zendy; Agustín Jacinto Zavala | Zendy; Pascal Retailleau | Zendy; Bogdan I. Iorga | Zendy; Thierry Naas | Zendy

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Genetic and Biochemical Characterization of OXA-535, a Distantly Related OXA-48-Like β-Lactamase

Author(s) -

Laura Dabos,

Agnès B. Jousset,

Rémy A. Bonnin,

Nicolas Fortineau,

Agustín Jacinto Zavala,

Pascal Retailleau,

Bogdan I. Iorga,

Thierry Naas

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01198-18

Subject(s) - genetics , biology , ertapenem , chromosome , peptide sequence , gene , sequence (biology) , microbiology and biotechnology , escherichia coli , enterobacteriaceae

OXA-535 is a chromosome-encoded carbapenemase ofShewanella bicestrii JAB-1 that shares only 91.3% amino acid sequence identity with OXA-48. Catalytic efficiencies are similar to those of OXA-48 for most β-lactams, except for ertapenem, where a 2,000-fold-higher efficiency was observed with OXA-535.

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