4-Amino-2-Sulfanylbenzoic Acid as a Potent Subclass B3 Metallo-β-Lactamase-Specific Inhibitor Applicable for Distinguishing Metallo-β-Lactamase Subclasses | Zendy

Junichi Wachino | Zendy; Reo Kanechi | Zendy; Eriishino | Zendy; Marie Mochizuki | Zendy; Wanchun Jin | Zendy; Kouji Kimura | Zendy; Hiromasa Kurosaki | Zendy; Yoshichika Arakawa | Zendy

Open Access

4-Amino-2-Sulfanylbenzoic Acid as a Potent Subclass B3 Metallo-β-Lactamase-Specific Inhibitor Applicable for Distinguishing Metallo-β-Lactamase Subclasses

Author(s) -

Junichi Wachino,

Reo Kanechi,

Eriishino,

Marie Mochizuki,

Wanchun Jin,

Kouji Kimura,

Hiromasa Kurosaki,

Yoshichika Arakawa

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01197-19

Subject(s) - escherichia coli , subclass , biology , carbapenem , beta lactamase inhibitors , enterobacteriaceae , microbiology and biotechnology , minimum inhibitory concentration , biochemistry , antimicrobial , antibiotics , gene , genetics , antibody

The number of cases of infection with carbapenem-resistantEnterobacteriaceae (CRE) has been increasing and has become a major clinical and public health concern. Production of metallo-β-lactamases (MBLs) is one of the principal carbapenem resistance mechanisms in CRE. Therefore, developing MBL inhibitors is a promising strategy to overcome the problems of carbapenem resistance conferred by MBLs.

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