Antibacterial Activities of Iron Chelators against Common Nosocomial Pathogens | Zendy

Mitchell G. Thompson | Zendy; Brendan W. Corey | Zendy; Yuanzheng Si | Zendy; David W. Craft | Zendy; Daniel V. Zurawski | Zendy

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Antibacterial Activities of Iron Chelators against Common Nosocomial Pathogens

Author(s) -

Mitchell G. Thompson,

Brendan W. Corey,

Yuanzheng Si,

David W. Craft,

Daniel V. Zurawski

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01197-12

Subject(s) - deferiprone , deferoxamine , staphylococcus aureus , acinetobacter baumannii , microbiology and biotechnology , klebsiella pneumoniae , pseudomonas aeruginosa , escherichia coli , antibiotics , biology , bacteria , biochemistry , genetics , gene

The activities of iron chelators (deferoxamine, deferiprone, Apo6619, and VK28) were evaluated against type strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. Deferiprone, Apo6619, and VK28 each inhibited growth in standard and RPMI tissue culture medium, while deferoxamine had no effect. Additionally, time-kill assays revealed that VK28 had a bacteriostatic effect against S. aureus. Therefore, these newly developed iron chelators might provide a nontraditional approach for treatment of bacterial infections.

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