Potent Activities of Novel Imidazoles Lanoconazole and Luliconazole against a Collection of Azole-Resistant and -Susceptible Aspergillus fumigatus Strains | Zendy

Mahdi Abastabar | Zendy; Nooshin Rahimi | Zendy; Jacques F. Meis | Zendy; Narges Aslani | Zendy; Sadegh Khodavaisy | Zendy; Mojtaba Nabili | Zendy; Ali RezaeiMatehkolaei | Zendy; Koichi Makimura | Zendy; Hamid Badali | Zendy

Open Access

Potent Activities of Novel Imidazoles Lanoconazole and Luliconazole against a Collection of Azole-Resistant and -Susceptible Aspergillus fumigatus Strains

Author(s) -

Mahdi Abastabar,

Nooshin Rahimi,

Jacques F. Meis,

Narges Aslani,

Sadegh Khodavaisy,

Mojtaba Nabili,

Ali RezaeiMatehkolaei,

Koichi Makimura,

Hamid Badali

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01193-16

Subject(s) - azole , aspergillus fumigatus , microbiology and biotechnology , aspergillus , antifungal , biology

A collection of azole-susceptible (n = 141) and azole-resistant (n = 27)Aspergillus fumigatus isolates was tested against seven antifungal drugs, including the new imidazoles lanoconazole and luliconazole. The luliconazole and lanoconazole MIC90 values for the azole-susceptible strains were 0.001 μg/ml and 0.008 μg/ml, and those for the azole-resistant strains were 0.016 μg/ml and 0.032 μg/ml.

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