Low Central Nervous System Posaconazole Concentrations during Cerebral Phaeohyphomycosis | Zendy

F. Barde | Zendy; Eliane M. Billaud | Zendy; Lauriane Goldwirt | Zendy; Catherine Horodyckid | Zendy; Vincent Jullien | Zendy; Fanny Lanternier | Zendy; Philippe Lesprit | Zendy; Lucie Limousin | Zendy; Jérémie F. Cohen | Zendy; Olivier Lortholary | Zendy

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Low Central Nervous System Posaconazole Concentrations during Cerebral Phaeohyphomycosis

Author(s) -

F. Barde,

Eliane M. Billaud,

Lauriane Goldwirt,

Catherine Horodyckid,

Vincent Jullien,

Fanny Lanternier,

Philippe Lesprit,

Lucie Limousin,

Jérémie F. Cohen,

Olivier Lortholary

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01184-19

Subject(s) - posaconazole , phaeohyphomycosis , central nervous system , biology , pathology , medicine , antifungal , microbiology and biotechnology , itraconazole , endocrinology

Posaconazole diffusion has been documented in various organs, which contrasts with the scarce data available for the human central nervous system (CNS). We analyzed posaconazole concentrations in plasma and multiple CNS specimens taken from a patient who received posaconazole because of cerebral phaeohyphomycosis. Low posaconazole concentrations were obtained in CNS specimens, with sample-to-plasma ratios between 5% and 22%.

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