Association between Polymorphisms in the Pf mdr6 Gene and Ex Vivo Susceptibility to Quinine in Plasmodium falciparum Parasites from Dakar, Senegal | Zendy

Mathieu Gendrot | Zendy; Silman Diawara | Zendy; Marylin Madamet | Zendy; Mame Bou Kounta | Zendy; Sébastien Briolant | Zendy; Khalifa Ababacar Wade | Zendy; Mansour Fall | Zendy; Nicolas Benoît | Zendy; Aminata Nakoulima | Zendy; Rémy Amalvict | Zendy; Yaya Diémé | Zendy; Bécaye Fall | Zendy; Boubacar Wade | Zendy; Bakary Diatta | Zendy; Bruno Pradines | Zendy

Open Access

Association between Polymorphisms in the Pf mdr6 Gene and Ex Vivo Susceptibility to Quinine in Plasmodium falciparum Parasites from Dakar, Senegal

Author(s) -

Mathieu Gendrot,

Silman Diawara,

Marylin Madamet,

Mame Bou Kounta,

Sébastien Briolant,

Khalifa Ababacar Wade,

Mansour Fall,

Nicolas Benoît,

Aminata Nakoulima,

Rémy Amalvict,

Yaya Diémé,

Bécaye Fall,

Boubacar Wade,

Bakary Diatta,

Bruno Pradines

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01183-16

Subject(s) - plasmodium falciparum , biology , quinine , ex vivo , drug resistance , virology , multiple drug resistance , gene , apicomplexa , genetics , in vivo , malaria , immunology

Polymorphisms and the overexpression of transporter genes, especially of the ATP-binding cassette superfamily, have been involved in antimalarial drug resistance. The objective of this study was to use 77 Senegalese Plasmodium falciparum isolates to evaluate the association between the number of Asn residues in the polymorphic microsatellite region of the Plasmodium falciparum multidrug resistance 6 gene (Pf mdr6 ) and the ex vivo susceptibility to antimalarials. A significant association was observed between the presence of 7 or 9 Asn repeats and reduced susceptibility to quinine.

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