In Vitro Antifungal Activity of Isavuconazole against Madurella mycetomatis | Zendy

Wendy Kloezen | Zendy; Jacques F. Meis | Zendy; Ilse Curfs-Breuker | Zendy; Ahmed Hassan Fahal | Zendy; Wendy W. J. van de Sande | Zendy

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In Vitro Antifungal Activity of Isavuconazole against Madurella mycetomatis

Author(s) -

Wendy Kloezen,

Jacques F. Meis,

Ilse Curfs-Breuker,

Ahmed Hassan Fahal,

Wendy W. J. van de Sande

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01170-12

Subject(s) - itraconazole , antifungal , ketoconazole , mycetoma , echinocandins , triazole , biology , medicine , pharmacology , amphotericin b , microbiology and biotechnology , caspofungin , chemistry , dermatology , organic chemistry

Currently, therapy of black-grain mycetoma caused by Madurella mycetomatis consists of extensive debridement of the infected tissue combined with prolonged antifungal therapy with ketoconazole or itraconazole. In the present study, the in vitro activity of the new triazole isavuconazole toward M. mycetomatis was evaluated. Isavuconazole appeared to have high activity against M. mycetomatis, with MICs ranging from ≤0.016 to 0.125 μg/ml. Due to its favorable pharmacokinetics, isavuconazole could be a promising antifungal agent in the treatment of mycetoma.

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