Kluyvera ascorbata Strain from Hospital Sewage Carrying the mcr-1 Colistin Resistance Gene | Zendy

Feifei Zhao | Zendy; Zhiyong Zong | Zendy

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Kluyvera ascorbata Strain from Hospital Sewage Carrying the mcr-1 Colistin Resistance Gene

Author(s) -

Feifei Zhao,

Zhiyong Zong

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01165-16

Subject(s) - mcr 1 , plasmid , colistin , microbiology and biotechnology , gene , strain (injury) , biology , sewage , polymyxin , enterobacteriaceae , genetics , escherichia coli , antibiotics , anatomy , waste management , engineering

The newly identified plasmid-borne colistin resistance genemcr-1 was found in aKluyvera ascorbata isolate from hospital sewage in China.mcr-1 was carried by a 57-kb self-transmissible IncI2 plasmid. Unlike in a previous report,mcr-1 was not associated with ISApl1 and was inserted into a gene encoding a putative membrane protein by an unknown mechanism. This study highlights thatmcr-1 has spread to multiple bacterial species.

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