Open AccessIn Vitro Activities of 35 Double Combinations of Antifungal Agents against Scedosporium apiospermum and Scedosporium prolificans
Author(s) -
Manuel CuencaEstrella,
Ana AlastrueyIzquierdo,
Laura Alcázar-Fuoli,
Leticia BernalMartínez,
Alicia GómezLópez,
María José Buitrago,
Emilia Mellado,
Juan Luis Rodríguez-Tudela
Publication year - 2008
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01160-07
Subject(s) - scedosporium apiospermum , checkerboard , antifungal , echinocandins , biology , microbiology and biotechnology , broth microdilution , azole , pharmacology , minimum inhibitory concentration , voriconazole , antibiotics , caspofungin
Activities of 35 combinations of antifungal agents against Scedosporium spp. were analyzed by a checkerboard microdilution design and the summation of fractional concentration index. An average indifferent effect was detected apart from combinations of azole agents and echinocandins against Scedosporium apiospermum. Antagonism was absent for all antifungal combinations against both species.