Site-Directed Mutagenesis of the 1,3-β-Glucan Synthase Catalytic Subunit of Pneumocystis jirovecii and Susceptibility Assays Suggest Its Sensitivity to Caspofungin | Zendy

Amanda Luraschi | Zendy; Sophie Richard | Zendy; Philippe M. Hauser | Zendy

Open Access

Site-Directed Mutagenesis of the 1,3-β-Glucan Synthase Catalytic Subunit of Pneumocystis jirovecii and Susceptibility Assays Suggest Its Sensitivity to Caspofungin

Author(s) -

Amanda Luraschi,

Sophie Richard,

Philippe M. Hauser

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01159-18

Subject(s) - caspofungin , echinocandin , echinocandins , protein subunit , pneumocystis jirovecii , biology , enzyme , mutagenesis , biochemistry , microbiology and biotechnology , mutation , virology , antifungal , gene , voriconazole , human immunodeficiency virus (hiv) , fluconazole

The echinocandin caspofungin inhibits the catalytic subunit Gsc1 of the enzymatic complex synthesizing 1,3-β-glucan, an essential compound of the fungal wall. Studies with rodents showed that caspofungin is effective againstPneumocystis asci.

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