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The echinocandin caspofungin inhibits the catalytic subunit Gsc1 of the enzymatic complex synthesizing 1,3-β-glucan, an essential compound of the fungal wall. Studies with rodents showed that caspofungin is effective againstPneumocystis asci.

antimicrobial agents and chemotherapy

Site-Directed Mutagenesis of the 1,3-β-Glucan Synthase Catalytic Subunit of <i>Pneumocystis jirovecii</i> and Susceptibility Assays Suggest Its Sensitivity to Caspofungin

Site-Directed Mutagenesis of the 1,3-β-Glucan Synthase Catalytic Subunit of Pneumocystis jirovecii and Susceptibility Assays Suggest Its Sensitivity to Caspofungin