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Abla KPC-9 carbapenemase variant was discovered in isolates ofKlebsiella pneumoniae andEscherichia coli from a single patient. It differed frombla KPC-3 by one amino acid substitution (Val239Ala). TheK. pneumoniae isolate was typed as ST258, as was the epidemic Israeli KPC-3 clone.bla KPC-9 was found on a plasmid indistinguishable from pKpQIL that carriesbla KPC-3 in the epidemic clone. Compared to KPC-3, KPC-9 conferred less resistance to carbapenems and higher resistance to ceftazidime.

KPC-9, a Novel Carbapenemase from Clinical Specimens in Israel