Rapid Emergence of Echinocandin Resistance in Candida glabrata Resulting in Clinical and Microbiologic Failure | Zendy

James S. Lewis | Zendy; Nathan P. Wiederhold | Zendy; Brian L. Wickes | Zendy; Thomas F. Patterson | Zendy; James H. Jorgensen | Zendy

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Rapid Emergence of Echinocandin Resistance in Candida glabrata Resulting in Clinical and Microbiologic Failure

Author(s) -

James S. Lewis,

Nathan P. Wiederhold,

Brian L. Wickes,

Thomas F. Patterson,

James H. Jorgensen

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01144-13

Subject(s) - echinocandin , candida glabrata , micafungin , microbiology and biotechnology , biology , drug resistance , candida albicans , medicine , antifungal , fluconazole

We report a case of Candida glabrata candidemia that developed resistance to micafungin within 8 days of initiation of therapy in a patient without previous echinocandin exposure or other known risk factors for clinical or microbiological failure. Pre- and postresistant isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed a phenylalanine deletion at codon 659 within FKS2.

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