Open AccessRepurposing Quinacrine against Ebola Virus Infection In Vivo
Author(s) -
Thomas R. Lane,
Jason E. Comer,
Alexander N. Freiberg,
Peter B. Madrid,
Sean Ekins
Publication year - 2019
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01142-19
Subject(s) - repurposing , ebola virus , in vivo , ebolavirus , virology , drug repositioning , medicine , biology , virus , pharmacology , drug , microbiology and biotechnology , ecology
Quinacrine hydrochloride is a small-molecule, orally bioavailable drug that has been used clinically as an antimalarial and for many other applications. A machine learning model trained on Ebola virus (EBOV) screening data identified quinacrine as a potent (nanomolar)in vitro inhibitor.
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