Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA | Zendy

Mary Kate Alexander | Zendy; Anh Miu | Zendy; Angela Oh | Zendy; Mike Reichelt | Zendy; Hoangdung Ho | Zendy; Cécile Chalouni | Zendy; Sharada S. Labadie | Zendy; Lan Wang | Zendy; Jun Liang | Zendy; Nicholas N. Nickerson | Zendy; Huiyong Hu | Zendy; Yu Lan | Zendy; Miaofen Du | Zendy; Donghong Yan | Zendy; Summer Park | Zendy; Janice Kim | Zendy; Min Xu | Zendy; Benjamin D. Sellers | Zendy; Hans E. Purkey | Zendy; Nicholas J. Skelton | Zendy; Michael F. T. Koehler | Zendy; Jian Payandeh | Zendy; Vishal Verma | Zendy; Yiming Xu | Zendy; Christopher M. Koth | Zendy; Mireille Nishiyama | Zendy

Open Access

Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA

Author(s) -

Mary Kate Alexander,

Anh Miu,

Angela Oh,

Mike Reichelt,

Hoangdung Ho,

Cécile Chalouni,

Sharada S. Labadie,

Lan Wang,

Jun Liang,

Nicholas N. Nickerson,

Huiyong Hu,

Yu Lan,

Miaofen Du,

Donghong Yan,

Summer Park,

Janice Kim,

Min Xu,

Benjamin D. Sellers,

Hans E. Purkey,

Nicholas J. Skelton,

Michael F. T. Koehler,

Jian Payandeh,

Vishal Verma,

Yiming Xu,

Christopher M. Koth,

Mireille Nishiyama

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01142-18

Subject(s) - bacterial outer membrane , atp binding cassette transporter , lipopolysaccharide , bacteria , escherichia coli , biology , inner membrane , gram negative bacteria , biogenesis , biochemistry , atpase , microbiology and biotechnology , transporter , chemistry , membrane , enzyme , gene , genetics , endocrinology

There is a critical need for new antibacterial strategies to counter the growing problem of antibiotic resistance. In Gram-negative bacteria, the outer membrane (OM) provides a protective barrier against antibiotics and other environmental insults.

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