Efficacy of Posaconazole in a Murine Disseminated Infection by Can dida tropicalis | Zendy

Marçal Mariné | Zendy; F. Javier Pastor | Zendy; Josep Guarro | Zendy

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Efficacy of Posaconazole in a Murine Disseminated Infection by Can dida tropicalis

Author(s) -

Marçal Mariné,

F. Javier Pastor,

Josep Guarro

Publication year - 2009

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01136-09

Subject(s) - posaconazole , candida tropicalis , biology , microbiology and biotechnology , pharmacology , medicine , immunology , antifungal , voriconazole

We evaluated the efficacy of posaconazole againstCandida tropicalis in a systemic infection model with immunosuppressed mice. Posaconazole at 50 mg/kg of body weight/day prolonged the survival of mice and reduced the fungal tissue burden of mice infected with any of the five strains tested, with the exception of one strain that had a high MIC against this drug. Our results demonstrate the efficacy of posaconazole in the treatment of invasive murine infection caused byC. tropicalis .

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