Open AccessEfficacy of Posaconazole in a Murine Disseminated Infection by Can dida tropicalis
Author(s) -
Marçal Mariné,
Francisco Pastor,
Josep Guarro
Publication year - 2010
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01136-09
Subject(s) - posaconazole , candida tropicalis , biology , microbiology and biotechnology , pharmacology , medicine , immunology , antifungal , voriconazole
We evaluated the efficacy of posaconazole againstCandida tropicalis in a systemic infection model with immunosuppressed mice. Posaconazole at 50 mg/kg of body weight/day prolonged the survival of mice and reduced the fungal tissue burden of mice infected with any of the five strains tested, with the exception of one strain that had a high MIC against this drug. Our results demonstrate the efficacy of posaconazole in the treatment of invasive murine infection caused byC. tropicalis .