Open AccessZygomycetes Hyphae Trigger an Early, Robust Proinflammatory Response in Human Polymorphonuclear Neutrophils through Toll-Like Receptor 2 Induction but Display Relative Resistance to Oxidative Damage
Author(s) -
George Chamilos,
Russell E. Lewis,
Gregory A. Lamaris,
Thomas J. Walsh,
D. P. Kontoyiannis
Publication year - 2008
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01136-07
Subject(s) - proinflammatory cytokine , aspergillus fumigatus , hypha , microbiology and biotechnology , biology , downregulation and upregulation , interleukin 8 , immunology , respiratory burst , toll like receptor , inflammation , aspergillus oryzae , granulocyte , receptor , innate immune system , immune system , gene , enzyme , biochemistry
Human polymorphonuclear neutrophils (HPMNs) displayed attenuated hyphal damage associated with impaired O2 − release following exposure toRhizopus oryzae versus that withAspergillus fumigatus . Exposure of HPMNs toR. oryzae hyphae resulted in upregulation in Toll-like receptor 2 mRNA and a robust proinflammatory gene expression with rapid (1-h) induction of NF-κB pathway-related genes.