Zygomycetes Hyphae Trigger an Early, Robust Proinflammatory Response in Human Polymorphonuclear Neutrophils through Toll-Like Receptor 2 Induction but Display Relative Resistance to Oxidative Damage | Zendy

George Chamilos | Zendy; Russell E. Lewis | Zendy; Gregory A. Lamaris | Zendy; Thomas J. Walsh | Zendy; D. P. Kontoyiannis | Zendy

Open Access

Zygomycetes Hyphae Trigger an Early, Robust Proinflammatory Response in Human Polymorphonuclear Neutrophils through Toll-Like Receptor 2 Induction but Display Relative Resistance to Oxidative Damage

Author(s) -

George Chamilos,

Russell E. Lewis,

Gregory A. Lamaris,

Thomas J. Walsh,

D. P. Kontoyiannis

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01136-07

Subject(s) - proinflammatory cytokine , aspergillus fumigatus , hypha , microbiology and biotechnology , biology , downregulation and upregulation , interleukin 8 , immunology , respiratory burst , toll like receptor , inflammation , aspergillus oryzae , granulocyte , receptor , innate immune system , immune system , gene , enzyme , biochemistry

Human polymorphonuclear neutrophils (HPMNs) displayed attenuated hyphal damage associated with impaired O2 − release following exposure toRhizopus oryzae versus that withAspergillus fumigatus . Exposure of HPMNs toR. oryzae hyphae resulted in upregulation in Toll-like receptor 2 mRNA and a robust proinflammatory gene expression with rapid (1-h) induction of NF-κB pathway-related genes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research