Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery | Zendy

Mikhail V. Keniya | Zendy; M. Sabherwal | Zendy; Rajni K. Wilson | Zendy; Matthew A. Woods | Zendy; A. Sagatova | Zendy; Joel D. A. Tyndall | Zendy; Brian C. Monk | Zendy

Open Access

Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery

Author(s) -

Mikhail V. Keniya,

M. Sabherwal,

Rajni K. Wilson,

Matthew A. Woods,

A. Sagatova,

Joel D. A. Tyndall,

Brian C. Monk

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01134-18

Subject(s) - lanosterol , candida albicans , azole , ketoconazole , biology , microbiology and biotechnology , candida glabrata , fluconazole , itraconazole , antifungal , demethylase , fungicide , biochemistry , botany , sterol , cholesterol , epigenetics , gene

Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and treatments for superficial and disseminated fungal infections, but cure rates are not optimal for immunocompromised patients and individuals with comorbidities. The efficacy of azole drugs has also been reduced due to the emergence of drug-resistant fungal pathogens.

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