Complete Sequencing of Plasmids Containing bla OXA-163 and bla OXA-48 in Escherichia coli Sequence Type 131 | Zendy

Nicole Stoesser | Zendy; Anna E. Sheppard | Zendy; Gisele Peirano | Zendy; Robert Sebra | Zendy; Tarah Lynch | Zendy; Luke Anson | Zendy; Andrew Kasarskis | Zendy; Mary Motyl | Zendy; Derrick W. Crook | Zendy; Johann Pitout | Zendy

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Complete Sequencing of Plasmids Containing bla _OXA-163 and bla _OXA-48 in Escherichia coli Sequence Type 131

Author(s) -

Nicole Stoesser,

Anna E. Sheppard,

Gisele Peirano,

Robert Sebra,

Tarah Lynch,

Luke Anson,

Andrew Kasarskis,

Mary Motyl,

Derrick W. Crook,

Johann Pitout

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01130-16

Subject(s) - plasmid , escherichia coli , biology , genetics , gene , lineage (genetic) , enterobacteriaceae , sequence (biology) , sequence analysis

OXA-48-like enzymes have emerged as important extended-spectrum β-lactamases/carbapenemases in Escherichia coli sequence type 131 (ST131). We report the structures of the first fully sequenced bla OXA-163 plasmid and of two other bla OXA-48 plasmids in this lineage. bla OXA-163 was located on a 71-kb IncN plasmid with other resistance genes. bla OXA-48 was present on IncL/M plasmids, genetically similar to other bla OXA-48 plasmid sequences, and consistent with interspecies/interlineage spread. The presence of bla OXA-48-like genes on epidemic plasmids in ST131 is of concern.

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