Molecular Characterization of a Voriconazole-Resistant, Posaconazole-Susceptible Aspergillus fumigatus Isolate in a Lung Transplant Recipient in the United States | Zendy

José A. Vázquez | Zendy; Elias K. Manavathu | Zendy

Open Access

Molecular Characterization of a Voriconazole-Resistant, Posaconazole-Susceptible Aspergillus fumigatus Isolate in a Lung Transplant Recipient in the United States

Author(s) -

José A. Vázquez,

Elias K. Manavathu

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01130-15

Subject(s) - posaconazole , voriconazole , aspergillus fumigatus , microbiology and biotechnology , aspergillosis , biology , aspergillus , lung , medicine , immunology , antifungal

Molecular characterization ofcyp51A from the azole-resistantAspergillus fumigatus isolate 50593 from a lung transplant patient showed Y121F/T289A changes coupled with a 46-bp tandem repeat (TR46) on the promoter, whereascyp51A from the pretherapy isolate,A. fumigatus 47381, showed no changes. This is the first reported case ofA. fumigatus azole resistance due to Y121F/T289A/TR46 in the United States, suggesting that multiple mutational alterations ofcyp51A resulting in high-level azole resistance could occur during prolonged antifungal therapy.

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