In Vitro Activities of Doripenem and Six Comparator Drugs against 423 Aerobic and Anaerobic Bacterial Isolates from Infected Diabetic Foot Wounds | Zendy

Ellie J. C. Goldstein | Zendy; Diane M. Citron | Zendy; C. Vreni Merriam | Zendy; Yumi A. Warren | Zendy; Kerin L. Tyrrell | Zendy; Helen T. Fernandez | Zendy

Open Access

In Vitro Activities of Doripenem and Six Comparator Drugs against 423 Aerobic and Anaerobic Bacterial Isolates from Infected Diabetic Foot Wounds

Author(s) -

Ellie J. C. Goldstein,

Diane M. Citron,

C. Vreni Merriam,

Yumi A. Warren,

Kerin L. Tyrrell,

Helen T. Fernandez

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01128-07

Subject(s) - doripenem , ertapenem , proteus mirabilis , microbiology and biotechnology , bacteroides fragilis , imipenem , carbapenem , pseudomonas aeruginosa , biology , staphylococcus aureus , medicine , antibiotics , bacteria , antibiotic resistance , genetics

Against 182 anaerobe and 241 aerobe strains obtained from diabetic foot infections, doripenem was the most active carbapenem against Pseudomonas aeruginosa (MIC(90), 2 microg/ml), more active than imipenem against Proteus mirabilis, and ertapenem was more active against Escherichia coli and Klebsiella spp. The MIC(50) and MIC(90) values were < or =0.125 microg/ml for methicillin-sensitive Staphylococcus aureus and all streptococci and 0.25/1 for Bacteroides fragilis.

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