Open AccessPharmacokinetics of Intracameral Voriconazole Injection
Author(s) -
Ying-Cheng Shen,
Mei-Yen Wang,
Chun-Yuan Wang,
Tsun-Chung Tsai,
Hin-Yeung Tsai,
Hsin-Nung Lee,
Li-Chen Wei
Publication year - 2009
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01125-08
Subject(s) - voriconazole , pharmacokinetics , aqueous humor , endophthalmitis , pharmacology , medicine , microbiology and biotechnology , chemistry , ophthalmology , biology , antifungal
Elimination of voriconazole after intracameral injection exhibited an exponential decay with a half-life of 22 min. Voriconazole levels in the vitreous humor were below the detectable limit. The aqueous concentrations achieved with a 25-microg dose during the first 2 h were greater than the previously reported MICs of organisms most involved in fungal endophthalmitis. A rapid decline in intracameral concentration suggests that frequent supplementation of intracameral voriconazole may be required in clinical settings.
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