Open AccessEvolution of Multidrug Resistance in Plasmodium falciparum: a Longitudinal Study of Genetic Resistance Markers in the Greater Mekong Subregion
Author(s) -
Mallika Imwong,
Kanokon Suwannasin,
Suttipat Srisutham,
Ranitha Vongpromek,
Cholrawee Promnarate,
Aungkana Saejeng,
Aung Pyae Phyo,
Stéphane Proux,
Tiengkham Pongvongsa,
Chea Nguon,
Olivo Miotto,
Rupam Tripura,
Chau Nguyen Hoang,
Dysoley Lek,
Nghia Ho Dang Trung,
Thomas J. Peto,
James J Callery,
Rob W. van der Pluijm,
Chanaki Amaratunga,
Mavuto Mukaka,
Lorenz von Seidlein,
Mayfong Mayxay,
Nguyen Thuy-Nhien,
Paul N. Newton,
Nicholas Day,
Elizabeth A. Ashley,
F Nosten,
Frank Smithuis,
Mehul Dhorda,
Nicholas J. White,
Arjen M. Dondorp
Publication year - 2021
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01121-21
Subject(s) - piperaquine , mefloquine , plasmodium falciparum , artemisinin , malaria , drug resistance , artesunate , biology , multiple drug resistance , virology , combination therapy , dihydroartemisinin , medicine , pharmacology , genetics , immunology
Increasing resistance inPlasmodium falciparum to artemisinins and their artemisinin combination therapy (ACT) partner drugs jeopardizes effective antimalarial treatment. Resistance is worst in the Greater Mekong subregion.