Regional Resistance Surveillance Program Results for 12 Asia-Pacific Nations (2011) | Zendy

Rodrigo E. Mendes | Zendy; Myrna Mendoza | Zendy; Kirnpal Kaur Banga Singh | Zendy; Mariana Castanheira | Zendy; Jan M. Bell | Zendy; John Turnidge | Zendy; Stephen Lin | Zendy; Ronald N. Jones | Zendy

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Regional Resistance Surveillance Program Results for 12 Asia-Pacific Nations (2011)

Author(s) -

Rodrigo E. Mendes,

Myrna Mendoza,

Kirnpal Kaur Banga Singh,

Mariana Castanheira,

Jan M. Bell,

John Turnidge,

Stephen Lin,

Ronald N. Jones

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01121-13

Subject(s) - broth microdilution , amikacin , tigecycline , colistin , microbiology and biotechnology , linezolid , vancomycin , klebsiella pneumoniae , streptococcus pneumoniae , antibiotic resistance , methicillin resistant staphylococcus aureus , drug resistance , staphylococcus aureus , biology , medicine , antimicrobial , antibiotics , minimum inhibitory concentration , escherichia coli , bacteria , biochemistry , genetics , gene

The Regional Resistance Surveillance program monitored susceptibility rates and developing resistance by geographic region, including 12 Asia-Pacific (APAC) countries. Reference broth microdilution methods for susceptibility/interpretations were applied, processing 5,053 strains. Among Staphylococcus aureus isolates (37% methicillin-resistant S. aureus [MRSA], highest in South Korea [73%]), linezolid (LZD), tigecycline (TIG), and vancomycin were 100% active, but 33 and 34% of strains were levofloxacin (LEV) or macrolide resistant, respectively. Streptococcus pneumoniae was most resistant to β-lactams and macrolides (45%) but was LZD, LEV, and TIG susceptible (>98%). Extended-spectrum β-lactamase (ESBL) phenotype rates in Escherichia coli and Klebsiella spp. were 48 and 47%, respectively, and were highest in Taiwan, at 75 to 91%. The best anti-ESBL-phenotype agents were amikacin (81 to 96% susceptible), colistin (COL; >98%), TIG (>98%), and carbapenems (81 to 97%). Pseudomonas aeruginosa showed ≥20% resistance to all drugs except COL (99% susceptible). In conclusion, endemic evolving antimicrobial resistances in APAC nations show compromised roles for many commonly used antimicrobials.

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