Sensititre MycoTB Plate Compared to Bactec MGIT 960 for First- and Second-Line Antituberculosis Drug Susceptibility Testing in Tanzania: a Call To Operationalize MICs | Zendy

Scott K. Heysell | Zendy; Suporn Pholwat | Zendy; Stellah Mpagama | Zendy; Saumu J. Pazia | Zendy; Happy Kumburu | Zendy; Norah Ndusilo | Zendy; Jean Gratz | Zendy; Eric R. Houpt | Zendy; Gibson Kibiki | Zendy

Open Access

Sensititre MycoTB Plate Compared to Bactec MGIT 960 for First- and Second-Line Antituberculosis Drug Susceptibility Testing in Tanzania: a Call To Operationalize MICs

Author(s) -

Scott K. Heysell,

Suporn Pholwat,

Stellah Mpagama,

Saumu J. Pazia,

Happy Kumburu,

Norah Ndusilo,

Jean Gratz,

Eric R. Houpt,

Gibson Kibiki

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01117-15

Subject(s) - mycobacterium tuberculosis , tanzania , tuberculosis , second line , drug resistance , medicine , microbiology and biotechnology , first line , virology , biology , pathology , geography , environmental planning

MIC testing for Mycobacterium tuberculosis is now commercially available. Drug susceptibility testing by the MycoTB MIC plate has not been directly compared to that by the Bactec MGIT 960. We describe a case of extensively drug-resistant tuberculosis (XDR-TB) in Tanzania where initial MIC testing may have prevented acquired resistance. From testing on archived isolates, the accuracy with the MycoTB plate was >90% for important first- and second-line drugs compared to that with the MGIT 960, and clinically useful quantitative interpretation was also provided.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research